Humanized antibody and uses thereof

US6479284B1 · kind B1 · utility

Assignees

• DANA-FARBER CANCER INSTITUTE, INC. · US
• AVANT Immunotherapeutics, Inc. · US
• Chiron Corporation · US

Inventors

• Wayne A. Marasco · Wellesley, US
• Joyce Lavecchio · Boston, US
• Abner Mhashilkar · Houston, US
• Urban Ramstedt · Bethesda, US
• David B. Ring · Palo Alto, US
• Bridget Eberhardt · Rowley, US
• Julie Porter-Brooks · Westford, US

Key dates

• Filing date: Sep 12, 2000
• Grant date: Nov 12, 2002
• Expiry date: Sep 12, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A humanized antibody framework motif is described. Preferably, the motif is encoded by the VH gene of K5B8 and the VL gene of TR1.6. This humanized antibody preferably contains the variable region of a tat antibody.