Modification of mutated P53 gene in tumors by retroviral delivery of ribozyme A
US6482803B1 · kind B1 · utility
18Cited by
4References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 1, 1995 |
| Grant date | Nov 19, 2002 |
| Priority date | — |
| Expiry date | Jan 3, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses expression constructs and methods for employing them that result in the modulation of abnormal oncogene and tumor suppressor genes in a novel approach to cancer prevention and therapy. In one embodiment, an expression construct expresses a ribozyme that inactivates mutant p53 and also expresses the functional p53.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.