Epothilone derivatives and methods for making and using the same
US6489314B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 3, 2001 |
| Grant date | Dec 3, 2002 |
| Priority date | — |
| Expiry date | Apr 3, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to 16-membered macrocyclic compounds. In one aspect of the present invention, compounds of the formula are provided wherein:R1, R2, R3, and R5 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or alkylaryl;R4 is hydrogen, halogen, C1-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 haloalkyl, aryl, —C(═O)R6, —C(═O)OR6, —NR6R7 where R6 and R7 are each independently hydrogen, C1-C10 aliphatic, aryl or alkylaryl;W is O, NR8 where R8 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or alkylaryl;X is O, CH2 or a carbon-carbon double bond;Y is absent or a C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl; andAr is aryl; provided that 10,11-dehydroepothilone C is excluded.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.