Use of constitutive transport elements for host range control

US6492166B1 · kind B1 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Andrea Ferris · Hayward, US
• Stephen H. Hughes · Smithsburg, US

Key dates

• Filing date: Jan 19, 2001
• Grant date: Dec 10, 2002
• Expiry date: Jan 19, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/13043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An Avian-derived retroviral vector from which the Constitutive Transport Element (CTE) has been removed and replaced with a genetic fragment from a mammalian virus in order to produce a vector that is replication competent in at least one non-native cell type without the need for a “helper” virus, and that is unlikely to recombine with endogenous mammalian viruses, making it both safe and simple to use in research and gene-therapy applications.