Naphthamidine urokinase inhibitors

US6495562B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Milan Bruncko · Libertyville, US
• Christopher R. Dalton · Mundelein, US
• Vincent L. Giranda · Gurnee, US
• Jianchun Gong · Deerfield, US
• Willian J. McClellan · Waukegan, US
• Vicki Nienaber · Gurnee, US
• Todd W. Rockway · Gurnee, US
• Daryl Sauer · Pleasant Prairie, US
• Moshe Weitzberg · Highland Park, US

Key dates

• Filing date: Apr 25, 2001
• Grant date: Dec 17, 2002
• Expiry date: Apr 25, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.