Pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds

US6498252B1 · kind B1 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Frank Grams · Mannheim, DE
• Hans-Willi Krell · Penzberg, DE
• Herbert Leinert · Heppenheim, DE
• Ernesto Menta · Parma, IT
• Gerd Zimmermann · Eckental, DE

Key dates

• Filing date: Sep 29, 2000
• Grant date: Dec 24, 2002
• Expiry date: Sep 29, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I in whichR1 represents a substituted or unsubstituted phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylamino or phenylmethyl residue, andR2 represents an optionally substituted aryl or heteroaryl residue, with metallo-proteinase inhibitor activity.