Inhibitors of phospholipase enzymes

US6500853B1 · kind B1 · utility

Assignee

• Genetics Institute, LLC · US

Inventors

• Jasbir Seehra · Lexington, US
• John C. McKew · Ames, US
• Frank Eldridge Lovering · Acton, US
• Jean E. Bemis · Arlington, US
• Yibin Xiang · Dracut, US
• Lihren Chen · Cambridge, US
• John Knopf · Carlisle, US

Key dates

• Filing date: Oct 11, 2000
• Grant date: Dec 31, 2002
• Expiry date: Nov 28, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.