Gamma-heregulin
US6500941B1 · kind B1 · utility
1Cited by
0References
21Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 28, 2000 |
| Grant date | Dec 31, 2002 |
| Priority date | — |
| Expiry date | Feb 28, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/971
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel member of the heregulin superfamily has been identified which is designated “&ggr;-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. &ggr;-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of &ggr;-HRG nucleic acid for the recombinant production of &ggr;-HRG). &ggr;-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.