Spectroscopic measurement method using NMR

US6504368B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Alfred Ross · Lörrach, DE
• Gotz Schlotterbeck · Weil am Rhein, DE
• Hans Senn · Windisch, CH

Key dates

• Filing date: Apr 9, 2001
• Grant date: Jan 7, 2003
• Expiry date: Apr 9, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/483
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, for example a bundle of capillaries imitating a conventional NMR sample tube or a well plate, or three-dimensional arrangements, for example stacks of well plates. The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.