Thiazolidinone compounds useful as chemokine inhibitors

US6506751B1 · kind B1 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Stephanie Elizabeth Ault Justus · Livonia, US
• Helen Tsenwhei Lee · Ann Arbor, US
• Jason Keith Pontrello · Kalamazoo, US
• Bruce D. Roth · Ann Arbor, US
• Karen Sexton · Ann Arbor, US
• Michael William Wilson · Foster City, US

Key dates

• Filing date: Nov 2, 2000
• Grant date: Jan 14, 2003
• Expiry date: Nov 2, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of the Formula I wherein:Z is C or nothing, provided that when Z is nothing, R3 and R4 are nothing;A is S, S═O or O═S═O;R1 and R2 are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy, (un)substituted aryl, (un)substituted arylalkyl, (un)substituted heteroaryl or(un)substituted heteroarylakyl;R3 and R4 independently represent hydrogen, lower alkyl, cycloalkyl, aminoalkyl, mono- or dialkylaminoalkyl, (un)substituted aryl or (un)substituted heteroaryl;R5 represents a (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms; orR5 is (CR6R7)—(CH2)n—XR8R9;X is S or N;R6, R7, R8, R9, and n are as defined in the specification.The compounds are useful in the treatment and prevention of the AIDS virus. Intermediates useful in the preparation of the final products, pharmaceutical compositions containing the final products are also taught.