Methods of treating nitric oxide and cytokine mediated disorders
US6511800B1 · kind B1 · utility
Assignees
Inventor
Key dates
| Filing date | May 25, 2000 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | May 25, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/99
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP. Methods of treating a nitric oxide or cytokine mediated disorder in a cell comprising administering a biologically effective amount of at least one induction suppressor of an inducible nitric oxide synthase or a cytokine is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.