Tricyclic vasopressin agonists

US6511974B1 · kind B1 · utility

Assignee

• Wyeth, LLC · US

Inventors

• John P. Dusza · Nanuet, US
• Peter S. Chan · Suffern, US
• Jay D. Albright · Nanuet, US
• Jehan F. Bagli · Princeton, US
• Amedeo A. Failli · Princeton Junction, US
• Mark Anthony Ashwell · Plainsboro, US
• Albert J. Molinari · Princeton, US
• Thomas Joseph Caggiano · Levittown, US
• Eugene J. Trybulski · Princeton Junction, US

Key dates

• Filing date: Jul 24, 1998
• Grant date: Jan 28, 2003
• Expiry date: Jul 24, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new compounds selected from those of the general formula (I), or a pharmaceutically acceptable salt, ester or prodrug form thereof: wherein D, E and G are N or CH, which serve as vasopressin agonists and are useful in treating disorders such as diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, and the inability to temporarily delay urination and pharmaceutical compositions and methods for same.