D-proline derivatives

US6512001B1 · kind B1 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Cornelia Hertel · Münchenstein, CH
• Torsten Hoffmann · Weil am Rhein, DE
• Roland Jakob-Roetne · Inzlingen, DE
• Roger Norcross · Olsberg, CH

Key dates

• Filing date: Aug 10, 2000
• Grant date: Jan 28, 2003
• Expiry date: Sep 20, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D419/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New compounds have the formula: wherein R, R1, X and Y have the meanings described herein. Methods are set forth for synthesizing these compounds and using these compounds to treat diseases associated with amyloidosis, such as Alzheimer's disease, maturity onset diabetes mellitus, familial amyloid polyneuropathy, scrapie, and Kreuzfeld-Jacob disease.