Nucleoside modifications by palladium catalyzed methods
US6512106B2 · kind B2 · utility
1Cited by
12References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 15, 2002 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | Jan 15, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention discloses a method for the preparation of 2′-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.