Tricyclic alkylhydroxamate derivatives

US6512123B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Adelbert Grossmann · Murnau am Staffelsee, DE
• Wolfgang von der Saal · Rosenheim, DE
• Tim Sattelkau · Ludwigshafen, DE
• Ulrich Tibes · Starnberg, DE

Key dates

• Filing date: Apr 22, 2002
• Grant date: Jan 28, 2003
• Expiry date: Apr 22, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D313/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I wherein R1, R2, A, X, Y and Z have the meanings provided in the specification, and their enantiomers, diastereoisomers, racemates, pharmaceutically acceptable salts and mixtures thereof. These compounds have HDAC inhibitory activity for inhibiting cell proliferation. Also provided is a process of manufacturing these compounds.