Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
US6515126B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Feb 27, 2001 |
| Grant date | Feb 4, 2003 |
| Priority date | — |
| Expiry date | Feb 27, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of a compound of formula (I) wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises:(i) cyclising a compound of formula (II) in the presence of a suitable catalyst; and(ii) purifying and collecting the resultant compound of formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.