IL-13 receptor specific chimeric proteins and uses thereof

US6518061B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Raj K. Puri · Bethesda, US
• Waldemar Debinski · Winston-Salem, US
• Ira H. Pastan · Potomac, US
• Nicholas Obiri · Gaithersburg, US

Key dates

• Filing date: Feb 17, 1998
• Grant date: Feb 11, 2003
• Expiry date: Feb 17, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell bearing an IL-13 receptor. The method involves providing a chimeric molecule that comprises an effector molecule attached to a circularly permuted IL-13 (“cpIL-13”) that specifically binds an IL-13 receptor and contacting the tumor cell with the chimeric molecule. The compositions include chimeric molecules comprising effector molecules such as modified Pseudomonas exotoxin attached to a cpIL-13. The invention further provides vectors encoding the chimeric molecules.