P-thienylbenzylamides as agonists of angiotensin-(1-7) receptors, and methods of their preparation and use
US6538144B2 · kind B2 · utility
5Cited by
2References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 13, 2002 |
| Grant date | Mar 25, 2003 |
| Priority date | — |
| Expiry date | Mar 13, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to p-thienylbenzylamides of formula (I) in which R(1), R(2), R(3), R(4), R(5), R(6) and X have the meanings given in the description. The compounds of formula (I) are potent agonists of angiotensin-(1-7) receptors and are useful as pharmaceutically active compounds to treat and/or prevent hypertension; cardiac hypertrophy; cardiac insufficiency; coronary heart diseases, such as angina pectoris; and endothelial dysfunction or endothelial damage as a consequence, for example, of atherosclerotic processes or in association with diabetes mellitus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.