Pyrazolo-pyridine derivatives as ligands for GABA receptors
US6541484B2 · kind B2 · utility
5Cited by
0References
9Claims
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Key dates
| Filing date | Jun 14, 2002 |
| Grant date | Apr 1, 2003 |
| Priority date | — |
| Expiry date | Jun 14, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A class of substituted and/or ring-fused pyrazolo[3,4-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent on the pyrazole nitrogen atom adjacent the pyridine nucleus, and an optionally substituted cycloalkyl-alkoxy, aryl-alkoxy or heteroaryl-alkoxy substituent on the carbon atom adjacent the pyridine ring nitrogen atom, are selective ligands for GABAA receptors, in particular having high affinity for the &bgr;2 and/or &bgr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse neurological disorders, including anxiety and convulsions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.