Antigenic constructs of major histocompatibility complex class I antigens with specific carrier molecules, the preparation and use thereof

US6548067B1 · kind B1 · utility

Inventors

• Gerhard Seeman · Lollar, DE
• Klaus Bosslet · Marburg, DE
• Hans-Harald Sedlacek · Marburg, DE

Key dates

• Filing date: Jun 2, 1995
• Grant date: Apr 15, 2003
• Expiry date: Jun 2, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antigenic constructs which result from linkage of major histocompatibility complex (MHC) class I antigens with specific carrier molecules are described. The linkage is effected N- or C-terminally by covalent bonding or, for example, in the case of non-covalent bonding by an avidin/biotin bridge. The specific carrier molecules bind selectively to target cells and are preferably monoclonal antibodies. Processes of genetic manipulation for the preparation of such constructs are indicated. Antigenic constructs according to the invention are used to damage or eliminate target cells.