Nutrient medium for bacterial strains which overproduce riboflavin

US6551813B1 · kind B1 · utility

Assignee

• Roche Vitamins Inc. · US

Inventors

• John B. Perkins · Reading, US
• Alan Sloma · Davis, US
• Janice G. Pero · Lexington, US
• Randolph T. Hatch · Wellesley, US
• Theron Hermann · Arlington, US
• Thomas Erdenberger · Arlington, US

Key dates

• Filing date: May 6, 1999
• Grant date: Apr 22, 2003
• Expiry date: May 6, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/52
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.