Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists

US6566366B1 · kind B1 · utility

Assignees

• Aventis Pharma Deutschland GmbH · DE
• Genentech, Inc. · US

Inventors

• Karl-Heinz Scheunemann · Liederbach, DE
• Jochen Knolle · Kriftel, DE
• Amuschirwan Peyman · Kelkheim, DE
• David William Will · Schwalbach, DE
• Denis Carniato · Marcoussis, FR
• Jean-Francois Gourvest · Claye-Souilly, FR
• Thomas Gadek · Oakland, US
• Robert McDowell · San Francisco, US
• Sarah C. Bodary · San Francisco, US
• Robert Andrew Cuthbertson · Elmore, AU

Key dates

• Filing date: Mar 6, 2001
• Grant date: May 20, 2003
• Expiry date: Mar 6, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula and salts thereof wherein the substituents are defined as in accordance with the specification useful for the treatment of tumor growth, osteoporosis, inflammation and cardiovascular disorders.