Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds

US6569851B1 · kind B1 · utility

Assignees

• Elan Pharmaceuticals, Inc. · US
• ELI LILLY AND COMPANY · US

Inventors

• Richard Thompson · Frankfort, US
• Stephen Wilkie · Indianapolis, US
• Douglas Richard Stack · Fishers, US
• Eldon Vanmeter · Greenwood, US
• Qing Shi · Princeton, US
• Thomas C. Britton · Carmel, US
• James E. Audia · Indianapolis, US
• Jon K. Reel · Carmel, US
• Thomas E. Mabry · Indianapolis, US
• Bruce A. Dressman · Indianapolis, US
• Cynthia L. Cwi · Indianapolis, US
• Steven S. Henry · New Palestine, US
• Stacey L. McDaniel · Martinsville, US
• Russell Stucky · Indianapolis, US
• Warren J. Porter · Indianapolis, US

Key dates

• Filing date: Jun 22, 1999
• Grant date: May 27, 2003
• Expiry date: Jun 22, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.