Peptide analogs as irreversible interleukin-1&bgr; protease inhibitors
US6576614B1 · kind B1 · utility
2Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 20, 1999 |
| Grant date | Jun 10, 2003 |
| Priority date | — |
| Expiry date | Oct 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06191
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are compounds, compositions, and methods for inhibiting interleukin-1&bgr; protease activity, wherein the compounds are &agr;-substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1&bgr; converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.