Recombinant PR-3 and compositions thereof
US6586222B1 · kind B1 · utility
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25References
29Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 28, 1995 |
| Grant date | Jul 1, 2003 |
| Priority date | — |
| Expiry date | Feb 28, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/525
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is useful for discovering inhibitors of excessive release of mature, active TNF&agr;. Also disclosed are methods for the identification of inhibitors of the conversion of the pro-form of TNF&agr; to its mature active form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.