Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists

US6586413B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• The Trustees of the University of Pennsylvania · US

Inventors

• Bruce Liang · Avon, US
• Kenneth A. Jacobson · Silver Spring, US

Key dates

• Filing date: Mar 5, 2001
• Grant date: Jul 1, 2003
• Expiry date: Mar 5, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2a receptor, is administered to reduce or prevent ischemic damage to the heart.