Phenyl substituted pyridine and benzene derivatives

US6596773B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Michael Bos · Montréal, CA
• Guido Galley · Rheinfelden (Baden), DE
• Thierry Godel · Basel, CH
• Torsten Hoffmann · Weil am Rhein, DE
• Walter Hunkeler · Magden, CH
• Patrick Schnider · Bottmingen, CH
• Heinz Stadler · Basel, CH

Key dates

• Filing date: Jan 17, 2002
• Grant date: Jul 22, 2003
• Expiry date: Jan 17, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/135
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is a series of compounds formed from phenyl substituted pyridine or benzene derivatives and their pharmaceutically acceptable salts. These compounds have shown high affinity as antagonists to the NK-1 receptor.