Infectious papillomavirus pseudoviral particles

US6599739B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Douglas R. Lowy · Washington, US
• John T. Schiller · Silver Spring, US
• Richard Roden · Severna Park, US

Key dates

• Filing date: Mar 30, 2000
• Grant date: Jul 29, 2003
• Expiry date: Mar 30, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/916
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides an infectious papillomavirus pseudoviral particle useful in gene transfer comprising: (a) a papillomavirus vector DNA which comprises an E2 binding site and an expression cassette comprising a gene and a sequence controlling expression of said gene; and (b) a papillomavirus capsid which comprises L1 and L2 structural proteins, such that said capsid encapsidates said vector DNA, wherein said gene is derived from a first biological species and said L1 structural protein is derived from a second biological species and said first biological species is different from said second biological species.