Nitroxides as protectors against oxidatives stress

US6605619B1 · kind B1 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• James B. Mitchell · Damascus, US
• Amran Samuni · Tveria, IL
• William G. Degraff · Wheaton, US
• Stephen C. Hahn · Redwood City, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Aug 12, 2003
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/445
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal-independent nitroxide compound which is preferably represented by the formula wherein R1 is —CH3; R2 is —C2H5, —C3H7, —C4H9, —C5H11, —C6H13, —CH2—CH(CH3)2, —CHCH3C2H5, or —(CH2)7—CH3, or wherein R1 and R2 together form spirocyclopentane, spirocyclohexane, spirocycloheptane, spirocyclooctane, 5-cholestane, or norbornane, R3 is —O. or —OH, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable carrier, as antioxidants capable of protecting cells, tissues, organs, and whole organisms against the deleterious effects of harmful free radical species generated during oxidative stress.