Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof

US6627641B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Guido Francois · Oostende, BE
• Gerhard Bringmann · Würzburg, DE
• J. David Phillipson · Cranbrook, GB
• Michael R. Boyd · Mobile, US
• Laurent Aké Assi · Abidjan, CI
• Christoph Schneider · Würzburg, DE
• Georges Timperman · Wilrijk, BE

Key dates

• Filing date: Apr 16, 1997
• Grant date: Sep 30, 2003
• Expiry date: Apr 16, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining such derivatives, and methods of using such antimalarial compounds for the prevention of malaria infections in mammals and for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.