Patent · US Expired

Antibody variants

US6632926B1 · kind B1 · utility

60Cited by

3References

3Claims

0Family size

Assignee

Genentech, Inc. · US

Inventors

Yvonne Chen · San Mateo, US
Henry B. Lowman · El Granada, US
Yves Muller · Panketal, DE

Key dates

Filing date	Nov 16, 1999
Grant date	Oct 14, 2003
Priority date	—
Expiry date	Nov 16, 2019

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.