Caspase inhibitors and uses thereof
US6632962B2 · kind B2 · utility
12Cited by
0References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 3, 2001 |
| Grant date | Oct 14, 2003 |
| Priority date | — |
| Expiry date | Sep 22, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides novel compounds that are effective as inhibitors of caspase and cellular apoptosis. The invention also provides methods for using the compounds to treat caspase-mediated diseases in mammals. The compounds have the general formula I: wherein X is F or Cl; R1 is COOH, COO(alkyl), or an isostere thereof; and R2 is an aryl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.