Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
US6642051B1 · kind B1 · utility
56Cited by
8References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 20, 1998 |
| Grant date | Nov 4, 2003 |
| Priority date | — |
| Expiry date | Oct 20, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
High-efficiency AAV packaging constructs and methods for their use are provided. in the present invention. These high-efficiency packaging constructs comprise an activating element (such as the P1 sequence located within the AAV S1 integration site of human chromosome 19) amplifiably linked to one or more AAV packaging genes. The constructs may be either integrated into a mammalian cell genome or maintained episomally. Use of the high-efficiency AAV packaging vectors of the invention provides for controlled amplifiable production of rAAV vector constructs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.