Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases

US6642227B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Jingrong Cao · Newton, US
• Jeremy Green · Waltham, US
• Young-Choon Moon · Montgomery, US
• Jian Wang · Newton, US
• Mark Ledeboer · Acton, US
• Edmund Harrington · Plymouth, US
• Huai Gao · Arlington, US

Key dates

• Filing date: Apr 10, 2002
• Grant date: Nov 4, 2003
• Expiry date: May 30, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, Ra, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.