Substituted &bgr;-alanine derivatives as cell adhesion inhibitors

US6645939B1 · kind B1 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Philippe L. Durette · New Providence, US
• William K. Hagmann · Westfield, US
• Ihor E. Kopka · Hampton, US
• Malcolm MacCoss · Freehold, US
• Sander G. Mills · Scotch Plains, US
• Richard A. Mumford · Red Bank, US
• Plato A. Magriotis · Scotch Plains, US

Key dates

• Filing date: May 24, 1999
• Grant date: Nov 11, 2003
• Expiry date: May 24, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

&bgr;-Alanine derivatives of Formula I are antagonists of VLA-4 and/or &agr;4&bgr;7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.