Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
US6646124B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 2, 2002 |
| Grant date | Nov 11, 2003 |
| Priority date | — |
| Expiry date | Apr 2, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention encompasses structures of the Formula or the pharmaceutically acceptable non-toxic salts thereof wherein:X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; andY is (un)substituted alkyl, aryl, or heteroaryl,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.