Process for the preparation of amorphous atorvastatin calcium
US6646133B1 · kind B1 · utility
6Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 3, 2002 |
| Grant date | Nov 11, 2003 |
| Priority date | — |
| Expiry date | Jul 3, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/337
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols under heating and isolating the amorphous atorvastatin calcium precipitated after cooling. The atorvastatin calcium obtained is a known valuable agent useful in treating hyperlipidemia and hypercholestrolemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.