Process for the preparation of oligonucleotide compounds
US6649750B1 · kind B1 · utility
27Cited by
3References
57Claims
0Family size
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Key dates
| Filing date | Jan 5, 2000 |
| Grant date | Nov 18, 2003 |
| Priority date | — |
| Expiry date | Jan 5, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/11
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Synthetic processes are provided wherein high purity oligomers are prepared using support bound phosphoramidite protocols starting with a nucleoside or larger synthon linked to a support media through a nucleosidic heterocyclic base moiety. Intermediates undergoing depurination at the support linkage site are removed during the wash cycle. Also provided are compositions useful in such processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.