Benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions

US6656956B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Claudia Thies · Biberach, DE
• Christine Braun · Giubiasco, CH
• Ralf Anderskewitz · Laupheim, DE
• Horst Dollinger · Schemmerhofen, DE
• Pascale Pouzet · Biberach, DE
• Herbert Nar · Ochsenhausen, DE
• Kai Hasselbach · Biberach an der Riß, DE
• Hans Michael Jennewein · Wiesbaden, DE
• Bernd Disse · Ingelheim am Rhein, DE

Key dates

• Filing date: Feb 6, 2002
• Grant date: Dec 2, 2003
• Expiry date: Feb 6, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are carboxamide-substituted benzimidazole derivatives of general formula (I) wherein the groups X, R1, R2, R3 and R4 may have the meanings given in the claims and specification, processes for preparing them and the use of carboxamide-substituted benzimidazole derivatives as pharmaceutical compositions, particularly as pharmaceutical compositions with a tryptase-inhibiting activity.