Inhibition of gene transcription by polyamide DNA-binding ligands
US6660255B1 · kind B1 · utility
7Cited by
1References
7Claims
0Family size
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Key dates
| Filing date | Apr 25, 2000 |
| Grant date | Dec 9, 2003 |
| Priority date | — |
| Expiry date | Apr 25, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides polyamides suitable for modulating cellular or viral gene expression by binding to an identified target DNA sequence adjacent to the binding site of a minor groove transcription factor protein. The polyamides of the present invention are useful for the treatment of a human infected with a virus such as HIV-1. The polyamides of the present invention are also useful for the treatment of conditions, such as cancers, that result from the expression or over-expression of cellular genes, particularly oncogenes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.