Pregelatinized starch in a controlled release formulation

US6667060B1 · kind B1 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Roger Petrus Gerebern Vandecruys · Westerlo, BE
• Eugene Marie Jozef Jans · Meerhout, BE

Key dates

• Filing date: Sep 28, 2001
• Grant date: Dec 23, 2003
• Expiry date: Sep 28, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2866
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns the use of pregelatinized starch to prevent dose-dumping from a hydrophilic controlled release formulation. It also concerns a hydrophilic controlled release formulation, more in particular a hydrophilic controlled release matrix formulation, and solid dosage forms prepared therefrom, preferably for once daily oral administration. The hydrophilic controlled release formulation comprises pregelatinized starch, one or more active ingredients, one or more viscous hydrophilic polymers and optionally pharmaceutically acceptable formulating agents. Preferred hydrophilic polymers include hydroxypropyl cellulose and hydroxypropyl methylcellulose.