Delivery of therapeutic agents by gene therapy

US6669935B1 · kind B1 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• Genetic Therapy, Inc. · US

Inventors

• Edward H. Oldfield · Philomont, US
• Zvi Ram · Ramat Gan, IL
• Gerard J. McGarrity · Gaithersburg, US

Key dates

• Filing date: Dec 15, 1998
• Grant date: Dec 30, 2003
• Expiry date: Dec 15, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for treating a disease or disorder of a host by delivery of a therapeutic agent to the brain of the host, which comprises transducing endothelial cells of blood vessels located in the brain of a host in vivo with a vector including a polynucleotide encoding a therapeutic agent. The vector is administered intravascularly to the host, and the vector produces the therapeutic agent in the endothelial cells.