Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof
US6676946B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 27, 1999 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | Sep 27, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A carbohydrate peptide conjugate containing:(i) a carrier containing a dendrimeric poly-lysine enabling multiple epitopes to be covalently attached thereto,(ii) at least one peptide containing one T epitope or several identical or different T-epitopes,(iii) at least one carbohydrate moiety which is tumor antigen, or a derivative thereof, containing a B epitope, provided it is not a sialoside, or several identical or different epitopes, wherein said conjugate containing at least 3-lysines and up to 15 lysine covalently linked to one another, and wherein:(a) to the NH2 and of at least two lysine residues is bound at least one carbohydrate residue being not a sialoside, optionally substituted and containing an epitope and wherein the peptide containing one T epitope is covalently bound to the end of said carbohydrate which induces immune responses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.