Non-adenoviral gene product-based complementing cells for adenoviral vectors
US6677156B2 · kind B2 · utility
21Cited by
1References
37Claims
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Key dates
| Filing date | Jul 23, 2001 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | Jul 23, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10352
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.