Carbamate caspase inhibitors and uses thereof
US6689784B2 · kind B2 · utility
12Cited by
2References
59Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 29, 2001 |
| Grant date | Feb 10, 2004 |
| Priority date | — |
| Expiry date | Mar 29, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D279/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 and R5 are taken together with the intervening nitrogen to form heterocyclic ring and R is as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1&bgr; secretion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.