Pyridine-substituted pyrazolopyridine derivatives

US6693102B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Johannes-Peter Stasch · Wuppertal, DE
• Achim Feurer · Wilhelmsfeld, DE
• Stefan Weigand · Wuppertal, DE
• Elke Stahl · Bensberg, DE
• Dietmar Flubacher · Glückstadt, DE
• Cristina Alonso-Alija · Haan, DE
• Frank Wunder · Wuppertal, DE
• Dieter Lang · Velbert, DE
• Klaus Dembowsky · Boston, US
• Alexander Straub · Wuppertal, DE
• Elisabeth Perzborn · Wuppertal, DE

Key dates

• Filing date: Nov 1, 2001
• Grant date: Feb 17, 2004
• Expiry date: Nov 2, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new pyrazolopyridine derivatives of the formula (I) in which R1 represents 4-pyridinyl or 3-pyridinyl; R2 represents H, NH2 or halogen; and salts, isomers and hydrates thereof as stimulators of soluble guanylate cyclase and for use as agents for the treatment of cardiovascular disorders, hypertension, of thromboembolic disorders and ischaemia, sexual dysfunction or inflammation, and for the treatment of disorders of the central nervous system.