B-homoestra-1,3,5(10)-trienes as modulators of tubulin polymerization
US6696436B1 · kind B1 · utility
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4References
39Claims
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Key dates
| Filing date | Aug 16, 2002 |
| Grant date | Feb 24, 2004 |
| Priority date | — |
| Expiry date | Aug 16, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J63/004
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides B-ring expanded estra-1,3,5(10)-triene compounds of general formula (1) which modulate the polymerization of tubulin and/or the depolymerization of microtubules. The compounds have anti-angiogenic and anti-tumor activity. The invention also provides methods of preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirable angiogenesis. The compounds of the invention are also expected to have utility as research tools.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.