Assay for inhibitors of fatty-acid amide hydrolase
US6699682B2 · kind B2 · utility
30Cited by
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2Claims
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Key dates
| Filing date | Jun 28, 2001 |
| Grant date | Mar 2, 2004 |
| Priority date | — |
| Expiry date | Jun 28, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/6418
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of cis-9,10-octadecenoamide by FAAH leads to the formation of oleic acid, a compound without soporific activity. FAAH has be isolated and the gene encoding FAAH has been cloned, sequenced, and used to express recombinant FAAH. Inhibitors of FAAH are disclosed to block the hydrolase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.