Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles

US6706707B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Vincent Mutel · Mulhouse, FR
• Jens-Uwe Peters · Weil am Rhein, DE
• Juergen Wichmann · Basel, CH

Key dates

• Filing date: Nov 28, 2001
• Grant date: Mar 16, 2004
• Expiry date: Dec 6, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a compound and the use of the compound of the formula wherein R1, R2, R3, R4 and R5 are as defined in the description, A signifies —CH═CH— or —C≡C—; and B signifies wherein R6 to R26, X and Y are as defined in the specification or a pharmaceutically acceptable salt thereof, for use in pharmaceutical compositions for the treatment or prevention of mGluR5 receptor mediated disorders.