Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter

US6713300B1 · kind B1 · utility

Assignees

• University of Utah Research Foundation · US
• Baylor College of Medicine · US
• THE JOHNS HOPKINS UNIVERSITY · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Rando Allikmets · Frederick, US
• Kent L. Anderson · Houston, US
• Michael Dean · Frederick, US
• Mark Leppert · Salt Lake City, US
• Richard A. Lewis · Houston, US
• Yixin Li · Houston, US
• James R. Lupski · Houston, US
• Jeremy Nathans · Baltimore, US
• Amir Rattner · Baltimore, US
• Noah F. Shroyer · Houston, US
• Nanda Singh · Salt Lake City, US
• Philip Smallwood · Woodbine, US
• Hui Sun · Culver City, US

Key dates

• Filing date: Feb 27, 1998
• Grant date: Mar 30, 2004
• Expiry date: Feb 27, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01K2217/05
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.